ZOMBEX tells the story of a post-Katrina New Orleans as it deals with a new disaster, a zombie apocalypse. NOLA residents are no longer experiencing the depression and post-traumatic stress due to the trauma of the hurricane, thanks to the revolutionary ZOMBEX - a rogue, yet, "clinically-proven" anti-depressant pharmaceutical manufactured by a nefarious organization. For those who call the Big Easy their home, everything is just now turning around for them. Or, could it just be the drug, ZOMBEX, talking... Just as things are turning around for the city and its people, they once again must face a disaster of epic proportions. Only this time, they're dealing with the prospect of losing the people of New Orleans as they turn into the city's walking dead...

Young DJ Vantia Block is hosting a music show when two renegade hoodlums phone her and start making trouble. The situation changes rapidly as the kids drive to a passageway and get sawed to pieces by Leatherface while the shocked DJ listens the kids' screams. Local sheriff approaches Block and convinces her to play the recording made from the phone call on radio, hoping that the killers would show up.